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pFIB-c Calculator

How to Calculate pFIB-c

The pFIB-c predicts liver fibrosis risk in pediatric MASLD using a logistic regression model.

FORMULA

The pFIB-c is calculated by the following formula:


\( x = -5.155 \)
\( + (1.194 \times \text{Sex [boy = 1, girl = 0]}) \)
\( + (1.636 \times \text{Hypertension [yes = 1, no = 0]}) \)
\( + (0.019 \times \text{ALT [U/L]}) \)
\( + (0.633 \times \text{Weight z-score}) \)
\( + (0.079 \times \text{HOMA-IR}) \)
\( - (2.453 \times \text{Black ethnicity [yes = 1, no = 0]}) \)

\( \text{Liver fibrosis risk, \%} = \frac{e^{x}}{1 + e^{x}} \times 100 \)

Notes:

* Both the CDC and WHO have resources to assist in the calculation of a weight z-score.

** HOMA-IR score = (Fasting insulin, uIU/mL) * (Fasting glucose, mg/dL) / 405

Enter the values and calculate the result.

Note: Ensure valid inputs; ALT, insulin, and glucose positive.

Using the pFIB-c Calculator

This calculator aids in predicting liver fibrosis risk in pediatric patients with metabolic dysfunction–associated steatotic liver disease (MASLD).

Input sex, hypertension, ALT, weight z-score, fasting insulin, fasting glucose, black ethnicity. The calculator computes HOMA-IR and outputs risk %, risk level, and correlated fibrosis stage.

Example 1: Boy, No hypertension, ALT 50, Weight z-score 1, Fasting Insulin 10, Fasting Glucose 81, No black ethnicity.


  1. Sex: 1
  2. Hypertension: 0
  3. ALT: 50
  4. Weight z-score: 1
  5. Fasting Insulin: 10
  6. Fasting Glucose: 81
  7. HOMA-IR: (10 * 81) / 405 ≈ 2
  8. Black ethnicity: 0
  9. x ≈ -5.155 +1.194 +0 +0.95 +0.633 +0.158 +0 ≈ -2.22
  10. Risk ≈ 9.82%
  11. Risk Level: Low
  12. Stage: F0-F1

Example 2: Girl, Yes hypertension, ALT 100, Weight z-score 2, Fasting Insulin 20, Fasting Glucose 100, Yes black ethnicity.


  1. Sex: 0
  2. Hypertension: 1
  3. ALT: 100
  4. Weight z-score: 2
  5. Fasting Insulin: 20
  6. Fasting Glucose: 100
  7. HOMA-IR: (20 * 100) / 405 ≈ 4.938
  8. Black ethnicity: 1
  9. x ≈ -5.155 +0 +1.636 +1.9 +1.266 +0.390 -2.453 ≈ -0.416
  10. Risk ≈ 39.75%
  11. Risk Level: Elevated
  12. Stage: ≥F2

Use for risk stratification.

Common FAQ

Below are frequently asked questions about pFIB-c:

  • Q: What is pFIB-c?
    A: Predicts liver fibrosis risk in pediatric MASLD.
  • Q: What is HOMA-IR?
    A: Homeostatic Model Assessment for Insulin Resistance.
  • Q: How to get weight z-score?
    A: Use CDC or WHO resources.
  • Q: How accurate?
    A: Validated in studies for pediatric patients.
  • Q: For which patients?
    A: Pediatric patients with MASLD.

Advice on Interpreting Results

Use to inform discussions on risks and care planning.

Facts & Figures

Interpretation:

pFIB-c Score (Probability) Risk Level of Significant Liver Fibrosis Correlated Fibrosis Stage
<0.226 (22.6%) Low F0-F1
≥0.226 (22.6%) Elevated ≥F2
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