Steatosis-Associated Fibrosis Estimator (SAFE) Score Calculator

SAFE Score Calculator

Age (years):

BMI (kg/m²):

Diabetes:

AST (U/L):

ALT (U/L):

Albumin (g/dL):

Total Protein (g/dL):

Platelets (10⁹/L):

Result:

Risk Level of Moderate (F2+) Fibrosis:

Calculated Globulin (g/dL):

How to Calculate SAFE Score

The SAFE Score estimates the risk of liver fibrosis in patients with steatosis using a logistic regression model.

FORMULA

The SAFE Score is calculated by the following formula:

\( \text{SAFE Score} = -75 \)
\( + (2.97 \times \text{Age [years]}) \)
\( + (5.99 \times \text{BMI [kg/m², capped at 40]}) \)
\( + (62.85 \times \text{Diabetes [yes = 1, no = 0]}) \)
\( + (154.85 \times \ln(\text{AST [U/L]})) \)
\( + (-58.23 \times \ln(\text{ALT [U/L]})) \)
\( + (195.48 \times \ln(\text{Globulin [g/dL]})) \)
\( + (-141.61 \times \ln(\text{Platelets [×10⁹/L]})) \)

Notes:

* Globulin is calculated as Total Protein (g/dL) - Albumin (g/dL).

** BMI is capped at a maximum of 40.

Enter the values and calculate the result.

Note: Ensure valid inputs; all values must be positive, and globulin > 0.

Using the SAFE Score Calculator

This calculator aids in estimating the risk of moderate or higher liver fibrosis in patients with steatosis.

Input age, BMI, diabetes status, AST, ALT, albumin, total protein, platelets. The calculator computes globulin and outputs the SAFE Score and risk level.

Example 1: Age 50, BMI 30, No diabetes, AST 40, ALT 50, Albumin 4, Total Protein 7, Platelets 250.

Age: 50
BMI: 30 (capped at 30)
Diabetes: 0
AST: 40, ln(AST) ≈ 3.689
ALT: 50, ln(ALT) ≈ 3.912
Globulin: 7 - 4 = 3, ln(Globulin) ≈ 1.099
Platelets: 250, ln(Platelets) ≈ 5.521
Score ≈ -75 + (2.97*50) + (5.99*30) + (62.85*0) + (154.85*3.689) + (-58.23*3.912) + (195.48*1.099) + (-141.61*5.521) ≈ -10.23
Risk Level: Low

Example 2: Age 60, BMI 45, Yes diabetes, AST 80, ALT 60, Albumin 3.5, Total Protein 6.5, Platelets 150.

Age: 60
BMI: 45 (capped at 40)
Diabetes: 1
AST: 80, ln(AST) ≈ 4.382
ALT: 60, ln(ALT) ≈ 4.094
Globulin: 6.5 - 3.5 = 3, ln(Globulin) ≈ 1.099
Platelets: 150, ln(Platelets) ≈ 5.011
Score ≈ -75 + (2.97*60) + (5.99*40) + (62.85*1) + (154.85*4.382) + (-58.23*4.094) + (195.48*1.099) + (-141.61*5.011) ≈ 112.45
Risk Level: High

Use for risk stratification.

Common FAQ

Below are frequently asked questions about SAFE Score:

Q: What is SAFE Score?
A: Steatosis-Associated Fibrosis Estimator to predict risk of liver fibrosis.
Q: How is globulin calculated?
A: Total Protein minus Albumin.
Q: Why cap BMI at 40?
A: As per the model to avoid overestimation in extreme obesity.
Q: How accurate?
A: Validated in studies for patients with steatosis.
Q: For which patients?
A: Adults with suspected or confirmed steatosis-associated liver disease.

Advice on Interpreting Results

Use to inform discussions on risks and care planning.

Facts & Figures

Interpretation:

SAFE Score	Risk of Moderate (F2+) Fibrosis
<0	Low
0-99	Intermediate
≥100	High